Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle.

  title={Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle.},
  author={Eric Hajduch and Franck Rencurel and Anudharan Balendran and Ian H. Batty and C. Peter Downes and Harinder S Hundal},
  journal={The Journal of biological chemistry},
  volume={274 19},
In this study we show that serotonin (5-hydroxytryptamine (5-HT)) causes a rapid stimulation in glucose uptake by approximately 50% in both L6 myotubes and isolated rat skeletal muscle. This activation is mediated via the 5-HT2A receptor, which is expressed in L6, rat, and human skeletal muscle. In L6 cells, expression of the 5-HT2A receptor is developmentally regulated based on the finding that receptor abundance increases by over 3-fold during differentiation from myoblasts to myotubes… CONTINUE READING


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