Serotonin (5-HT1A-receptor) agonist-induced collecting duct vacuolation and renal papillary necrosis in the rat.

@article{Rinke1998SerotoninA,
  title={Serotonin (5-HT1A-receptor) agonist-induced collecting duct vacuolation and renal papillary necrosis in the rat.},
  author={Matthias Rinke and Ernst M. Bomhard and Heinz Hildebrand and Karl H. Leser and Ingo Loof and Ch. R{\"u}hl-Fehlert},
  journal={Toxicologic pathology},
  year={1998},
  volume={26 1},
  pages={152-9}
}
General anxiety in humans is treated with azaspirodecanedions, which act through a reduction of serotonin transmission. Ipsapirone also represents a serotonin (5-HT1A) receptor agonist and was under development as an anxiolytic drug. Histopathologic evaluation of animal experiments revealed cellular swelling and/or vacuolation of renal papillary and medullary collecting duct (MCD) epithelium in rats but not in dogs or mice. The changes ensued already after 1 wk of dosing and were first… CONTINUE READING

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