Serotonin: good or bad for bone.

  title={Serotonin: good or bad for bone.},
  author={Marie-Christine de Vernejoul and Corinne Collet and Yasmine Chabbi-Achengli},
  journal={BoneKEy reports},
Besides its action as a neurotransmitter, serotonin has multiple physiological functions in several peripheral organs. Recently, Yadav et al. suggested that peripheral serotonin produced in the gut was a major negative regulator of osteoblast proliferation. These data were challenged by Cui et al. that showed no change in bone density in mature mice with a global invalidation of tryptophan hydroxylase 1, the enzyme responsible of serotonin synthesis in the periphery. In this context, we showed… CONTINUE READING
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Decreased osteoclastogenesis in serotonindefi cient mice

  • Y Chabbi-Achengli, AE Coudert, J Callebert, V Geoffroy, F Cote, C Collet
  • Proc Natl Acad Sci USA
  • 2012

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