Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release

  title={Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release},
  author={George K. Aghajanian and Gerard J. Marek},
  journal={Brain Research},

The Role of Kv1.2-Containing Potassium Channels in Serotonin-Induced Glutamate Release from Thalamocortical Terminals in Rat Frontal Cortex

Results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals, suggesting a common mechanism of action.

Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.

It is argued that 5-HT(2) receptors couple through G(alphaq) proteins to trigger a phospholipase Cbeta/inositol trisphosphate signaling cascade resulting in the mobilization of intracellular Ca(2+), activation of calcineurin, and inhibition of Ca(v)1.2 L-type Ca( 2+) currents.

Serotonin–Glutamate Interactions: A New Target for Antipsychotic Drugs

Serotonin Modulates Fast-Spiking Interneuron and Synchronous Activity in the Rat Prefrontal Cortex through 5-HT1A and 5-HT2A Receptors

It is found that 5-HT, released by electrical stimulation of the dorsal raphe nucleus (DRN) in anesthetized rats, regulates the frequency and the amplitude of slow (<2 Hz) waves in the PFC via 5- HT2A receptors (5-HT2ARs); this results may provide insight into impaired serotonergic control of network activity in psychiatric illnesses.

Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat.

The specific induction of EPSCs in layer V neurons suggests that 5-HT preferentially modulates the output neurons of the frontal cortex, as well as the pattern of thalamic projections in frontal cortex.

Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex*

This study suggests that serotonin, via 5- HT1A and 5-HT2A/C receptor activation, regulates NMDAR functions in PFC neurons in a counteractive manner.

Serotonergic Regulation of Membrane Potential in Developing Rat Prefrontal Cortex: Coordinated Expression of 5-Hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 Receptors

Together, these results outline coordinated changes in the serotonergic regulation of cortical excitability at a time of extensive synaptic development and thus suggest a key role for these receptor subtypes in the postnatal development of the prefrontal cortex.

Serotonergic Modulation of Spontaneous and Evoked Transmitter Release in Layer II Pyramidal Cells of Rat Somatosensory Cortex.

Investigation of how serotonin (5-HT) modulates transmitter release in layer II pyramidal cells of rat barrel cortex found EPSC reduction, together with enhanced spontaneous noise in a restricted subset of inputs, could temporarily diminish the signal-to-noise ratio and affect the computation in the neocortical microcircuit.



5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus.

  • R. ShenR. Andrade
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1998
Results interpret these results to indicate that 5-HT2 receptors activate GABAergic interneurons in the slice, leading to an increase in GABAergic synaptic activity onto pyramidal cells of the CA1 region.

Transient and long‐lasting actions of 5‐HT on rat dentate gyrus neurones in vitro.

It is concluded that 5‐HT hyperpolarizes granule cells via postsynaptic 5‐ HT1A receptors and increases spontaneous GABA release from inhibitory interneurones via the activation of5‐HT3 receptors and/or 5‐ht2 receptors.

5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites.

These findings reconcile the data on the receptor's cortical physiology and localization by establishing that 5-HT2A receptors are located postsynaptically and presynaptically, and demonstrating that pyramidal neurons constitute the major 5- HT2A-receptor-expressing cells in the cortex, and supporting the view that the apical dendritic field proximal to the pyramsidal cell soma is the "hot spot" for 5-ht2A's physiological actions.

Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex.

It is concluded that 5-HT presynaptically inhibits the release of excitatory amino acids at synapses onto prefrontal pyramidal neurons and atsynapses onto local feed-forward inhibitory interneurons.