Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release

@article{Aghajanian1999SerotoninV5,
  title={Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release},
  author={G. Aghajanian and G. Marek},
  journal={Brain Research},
  year={1999},
  volume={825},
  pages={161-171}
}
Previously, serotonin (5-HT) was found to induce a marked increase in glutamatergic spontaneous excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpectedly, although the effect of 5-HT was Ca2+-dependent and tetrodotoxin-sensitive, it did not appear to involve the activation of excitatory afferent impulse flow… Expand
306 Citations
The Role of Kv1.2-Containing Potassium Channels in Serotonin-Induced Glutamate Release from Thalamocortical Terminals in Rat Frontal Cortex
  • 104
  • PDF
Serotonin–Glutamate Interactions: A New Target for Antipsychotic Drugs
  • 48
  • PDF
Potentiation of excitatory serotonergic responses by MK-801 in the medial prefrontal cortex
  • 18
Hallucinogen-Induced UP States in the Brain Slice of Rat Prefrontal Cortex: Role of Glutamate Spillover and NR2B-NMDA Receptors
  • 43
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus.
  • R. Shen, R. Andrade
  • Biology, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1998
  • 103
Transient and long‐lasting actions of 5‐HT on rat dentate gyrus neurones in vitro.
  • 113
Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex.
  • 183
...
1
2
3
4
...