Serotonergic vulnerability and depression: assumptions, experimental evidence and implications

  title={Serotonergic vulnerability and depression: assumptions, experimental evidence and implications},
  author={Linda A.W. Jans and Wim J. Riedel and Cardell Markus and Arjan Blokland},
  journal={Molecular Psychiatry},
In recent years, the term serotonergic vulnerability (SV) has been used in scientific literature, but so far it has not been explicitly defined. This review article attempts to elucidate the SV concept. SV can be defined as increased sensitivity to natural or experimental alterations of the serotonergic (5-HTergic) system. Several factors that may disrupt the 5-HTergic system and hence contribute to SV are discussed, including genetic factors, female gender, personality characteristics, several… CONTINUE READING
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