Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome

@article{Keszthelyi2014SerotonergicRO,
  title={Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome},
  author={D. Keszthelyi and F. Troost and D. Jonkers and H. Eijk and P. Lindsey and J. Dekker and W. Buurman and A. Masclee},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2014},
  volume={40}
}
Alterations in serotonergic (5‐HT) metabolism and/or intestinal integrity have been associated with irritable bowel syndrome (IBS). 

Paper Mentions

Interventional Clinical Trial
Serotonin, 5-hydroxytryptamin (5-HT), plays an important role in regulating the gastrointestinal functions. In this study we will modulate the serotonin system with acute… Expand
ConditionsIrritable Bowel Syndrome
InterventionDrug, Other
Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism – a preliminary study
  • D. Keszthelyi, F. Troost, +4 authors A. Masclee
  • Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2015
TLDR
The aim of this preliminary study was to assess the effect of the direct precursor of 5‐HT, 5‐hydroxytryptophan (5‐HTP), on systemic 5-HT metabolites and visceral perception and to assess potential differential responses between IBS and controls. Expand
Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders
TLDR
Intestinal permeability has been studied in small groups of IBS patients with contrasting findings and it is necessary to select patients with high intestinal permeability for IBS treatment. Expand
Increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea‐predominant irritable bowel syndrome: a preliminary explorative study
TLDR
Pre‐clinical evidence indicates that nerve growth factor (NGF) mediates visceral hypersensitivity and gut barrier dysfunction, via interactions with mast cells and sensory nerve fibres. Expand
Biomarkers for visceral hypersensitivity in patients with irritable bowel syndrome
  • Z. Mujagic, D. Jonkers, +9 authors A. Masclee
  • Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2017
Increased visceral sensitivity is observed in up to 60% of patients with Irritable Bowel Syndrome (IBS). Mucosal inflammation, altered neuroendocrine activity and intraluminal metabolic processes mayExpand
Markers for visceral hypersensitivity in patients with irritable bowel syndrome
  • S. Ludidi, Z. Mujagic, +5 authors A. Masclee
  • Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2014
TLDR
Aim of the study was to compare in detail a large group of hyper‐ vs normosensitive IBS patients with respect to epidemiological and clinical characteristics. Expand
Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review
TLDR
The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function, especially in the IBS-D and PI-IBS subtype. Expand
Chemical and molecular factors in irritable bowel syndrome: current knowledge, challenges, and unanswered questions.
TLDR
Current knowledge and unanswered questions in the pathobiology of the chemical and molecular factors in IBS are reviewed and how they may influence hypervigilance in the central nervous system in patients with IBS is appraised. Expand
Diverse Effects of Gut-Derived Serotonin in Intestinal Inflammation.
TLDR
The current review aims to provide an update on the role of enteric 5-HT and its immune mediators in the context of intestinal inflammation. Expand
Editorial: abnormal permeability and altered mucosal serotonin metabolism in the irritable bowel syndrome – is there a link?
  • R. Spiller
  • Medicine
  • Alimentary pharmacology & therapeutics
  • 2014
TLDR
This study was designed to assess health utilities and patient-reported outcomes during treatment with sofosbuvir regimens in a clinical trial setting and it is important to point out that this issue should be addressed in the future, after approval of these regimens, using data collected in clinical practice setting. Expand
Potential Determinants of Gastrointestinal Dysfunction in Autism Spectrum Disorders
Gastrointestinal (GI) dysfunction is a common comorbidity of autism spectrum disorders (ASD) and is associated with increased severity of characteristic autism-associated symptoms. However, theExpand
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