Serotonergic receptors in therapeutic approaches to gastrointestinal disorders.

@article{Neal2006SerotonergicRI,
  title={Serotonergic receptors in therapeutic approaches to gastrointestinal disorders.},
  author={Kathleen Bronwyn Neal and Joel C Bornstein},
  journal={Current opinion in pharmacology},
  year={2006},
  volume={6 6},
  pages={547-52}
}
Most of the cloned serotonin (5-HT) receptor subtypes are present on enteric neurons that control gastrointestinal function. Because of the wide distribution of 5-HT receptor subtypes in the gut, the precise actions of currently marketed drugs are unclear. Furthermore, efficacy of these drugs varies between individuals. Two recent advances provide important potential explanations for this phenomenon: polymorphisms have recently been discovered in the gene for the key enzyme in neural 5-HT… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Mast cell expression of the serotonin1A receptor in guinea pig and human intestine.

American journal of physiology. Gastrointestinal and liver physiology • 2013
View 4 Excerpts
Highly Influenced

Monoamines in the enteric nervous system

Histochemistry and Cell Biology • 2018
View 2 Excerpts

Involvement of 5-HT3 and 5-HT4 receptors in colonic motor patterns in rats.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society • 2015

Serotonin in the Gut: What Does It Do?

Front. Neurosci. • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…