Serotonergic receptors in therapeutic approaches to gastrointestinal disorders.

  title={Serotonergic receptors in therapeutic approaches to gastrointestinal disorders.},
  author={Kathleen Bronwyn Neal and Joel C Bornstein},
  journal={Current opinion in pharmacology},
  volume={6 6},
Most of the cloned serotonin (5-HT) receptor subtypes are present on enteric neurons that control gastrointestinal function. Because of the wide distribution of 5-HT receptor subtypes in the gut, the precise actions of currently marketed drugs are unclear. Furthermore, efficacy of these drugs varies between individuals. Two recent advances provide important potential explanations for this phenomenon: polymorphisms have recently been discovered in the gene for the key enzyme in neural 5-HT… CONTINUE READING

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