Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants.

@article{Politis2010SerotonergicNM,
  title={Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants.},
  author={Marios Politis and Kit Wu and Clare M Loane and Niall Quinn and David J. Brooks and Stig Rehncrona and Anders Bjorklund and Olle Lindvall and Paola Piccini},
  journal={Science translational medicine},
  year={2010},
  volume={2 38},
  pages={38ra46}
}
Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of cell-based therapies for Parkinson's disease. The mechanisms underlying these dyskinesias are not well understood, and it is not known whether they are the same as in the dyskinesias induced by l-dopa treatment. Using in vivo brain imaging, we show excessive serotonergic innervation in the grafted… CONTINUE READING
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A second case report

  • J. H. Kordower, Y. Chu, R. A. Hauser, C. W. Olanow, T. B. Freeman, Transplanted dopaminergic neurons develop PD pathologic changes
  • Mov. Disord. 23, 2303–2306
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1 Excerpt

Differing patterns of striatal 18 F - dopa uptake in Parkinson ’ s disease , multiple system atrophy , and progressive supranuclear palsy

  • V. Ibanez, G. V. Sawle, +5 authors R. S. Frackowiak
  • J . Cereb . Blood Flow Metab .
  • 2007

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