Serotonergic neuromodulation of peripheral nociceptors.

  title={Serotonergic neuromodulation of peripheral nociceptors.},
  author={Dayna R. Loyd and Michael A. Henry and Kenneth M Hargreaves},
  journal={Seminars in cell & developmental biology},
  volume={24 1},
Nociception, the encoding and processing of noxious environmental stimuli by sensory neurons, functions to protect an organism from bodily damage. Activation of the terminal endings of certain sensory neurons, termed nociceptors, triggers a train of impulses to neurons in the spinal cord. Signals are integrated and processed in the dorsal spinal cord and then projected to the brain where they elicit the perception of pain. A number of neuromodulators that can affect nociceptors are released in… CONTINUE READING