Serotonergic modulation of social interactions in isolated male mice

@article{Olivier2004SerotonergicMO,
  title={Serotonergic modulation of social interactions in isolated male mice},
  author={Berend Olivier and Jan Mos and Jan van der Heyden and Jan de Hartog},
  journal={Psychopharmacology},
  year={2004},
  volume={97},
  pages={154-156}
}
Several serotonergic drugs were tested in isolation-induced aggressive behavior in male mice using ethological methodology. Eltoprazine, a mixed 5-HT1 agonist, reduced aggression but enhanced social interest and exploration. Several 5-HT1A agonists (8-OH-DPAT, ipsapirone, buspirone, 5-Me-ODMT) and a 5-HT uptake blocker (fluvoxamine) also reduced aggression. Although these drugs somewhat differentially affect aggressive behavior, the isolation-induced paradigm alone is not sensitive enough to… 
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5-HT1A receptors are involved in mediation of isolation-induced aggressive behaviour in mice and the involvement of other 5-HT receptor subtypes needs further clarification.
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BEHAVIOURAL PHARMACOLOGY OF THE SERENIC, ELTOPRAZINE
In this paper the effects of serenics (eltoprazine and fluprazine) are described in several animal models for offensive agonistic, defensive agonistic and predatory behaviour. They are compared with…
Behavioral and pharmacogenetics of aggressive behavior.
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There are receptor populations in specific brain regions that preferentially modulate specific types of aggression and specific receptor subpopulations for GABA, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior.
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