Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects.

@article{Heninger1984SerotonergicFI,
  title={Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects.},
  author={George R. Heninger and Dennis S. Charney and David E. Sternberg},
  journal={Archives of general psychiatry},
  year={1984},
  volume={41 4},
  pages={398-402}
}
There is considerable evidence that serotonergic function may be reduced in the brains of depressed patients. Serotonin is an effective stimulant of prolactin release, and intravenous (IV) tryptophan (the amino acid precursor of serotonin), when administered to healthy subjects, produces a reliable and robust increase in serum prolactin level. To evaluate serotonergic function in depressed patients, we gave 25 patients and 19 age- and sex-matched controls tryptophan, 7 g IV. There was a marked… CONTINUE READING

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