Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain.

@article{Johnson2001SerotonergicEA,
  title={Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain.},
  author={David Edwin Johnson and Hans Rollema and Anne W. Schmidt and Aileen Mcharg},
  journal={European journal of pharmacology},
  year={2001},
  volume={425 3},
  pages={
          203-10
        }
}
In vivo microdialysis was used to assess the central serotonergic effects and extracellular brain levels of the 5-HT(1B/1D) receptor agonists eletriptan, zolmitriptan and sumatriptan in rats after intravenous and intracerebral administration, while their binding affinities and functional potencies were determined at 5-HT(1B), 5-HT(1D) and 5-HT(1A) receptors. In vitro studies showed that all three triptans are high affinity, full agonists at 5-HT(1B/1D) receptors, but that sumatriptan is… CONTINUE READING

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