Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.

  title={Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.},
  author={Tero Linnanen and Magnus Brisander and Nina Mohell and Anette M. Johansson},
  journal={Bioorganic & medicinal chemistry letters},
  volume={11 3},
Novel rigidified (R)-aporphine derivatives were synthesized from (R)-1,11-carbonylaporphine by ring expansion reactions. The structures of the novel analogues were assigned by NMR spectroscopy and X-ray crystallography. The compounds showed moderate affinities and selectivities at serotonin S-HT1A and 5-HT7 and dopamine D2A receptors.