Serotonergic and Noradrenergic Pathways Are Required for the Anxiolytic-like and Antidepressant-like Behavioral Effects of Repeated Vagal Nerve Stimulation in Rats
@article{Furmaga2011SerotonergicAN, title={Serotonergic and Noradrenergic Pathways Are Required for the Anxiolytic-like and Antidepressant-like Behavioral Effects of Repeated Vagal Nerve Stimulation in Rats}, author={Havan Furmaga and Aparna P. Shah and Alan Frazer}, journal={Biological Psychiatry}, year={2011}, volume={70}, pages={937-945} }
79 Citations
Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine
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The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus.
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Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist
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Comparison of ΔFosB Immunoreactivity Induced by Vagal Nerve Stimulation with That Caused by Pharmacologically Diverse Antidepressants
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Serotonergic transmission is required for the anxiolytic-like behavioral effects of YL-IPA08, a selective ligand targeting TSPO
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Hippocampal activation of 5‐HT1B receptors and BDNF production by vagus nerve stimulation in rats under chronic restraint stress
- Biology, PsychologyThe European journal of neuroscience
- 2019
The results suggest that VNS‐mediated serotonergic input via 5‐HT1B receptors into the hippocampal neurons may activate BDNF pathway and improve depressive‐like behaviors in CRS animals.
Activation of signaling pathways downstream of the brain-derived neurotrophic factor receptor, TrkB, in the rat brain by vagal nerve stimulation and antidepressant drugs.
- BiologyThe international journal of neuropsychopharmacology
- 2014
Western blot analysis was used to characterize activation due to phosphorylation in the hippocampus of down-stream pathways linked to specific key tyrosine residues on TrkB after either acute or chronic administration of VNS and traditional antidepressant drugs.
Comparison of the Antidepressant-Like Effects of Estradiol and That of Selective Serotonin Reuptake Inhibitors in Middle-Aged Ovariectomized Rats
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- 2016
The potency of estradiol to produce effects consistent with inhibition of the SERT was not only decreased in older rats but its effects were markedly diminished the longer hormonal depletion occurred, and the ability of SSRIs to inhibit the Sertraline was not affected either by age or the length of hormonal depletion.
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