Serotonergic and GABAergic neurons in the medial rostral ventral medulla express kappa-opioid receptor immunoreactivity.

@article{Kalyuzhny1999SerotonergicAG,
  title={Serotonergic and GABAergic neurons in the medial rostral ventral medulla express kappa-opioid receptor immunoreactivity.},
  author={Alexander E. Kalyuzhny and Martin W Wessendorf},
  journal={Neuroscience},
  year={1999},
  volume={90 1},
  pages={229-34}
}
Activation of kappa-opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu-opioid receptors in the periaqueductal gray matter. Previous studies have suggested that the cells associated with this effect might contain serotonin. In the present study, we investigated the relationship of the cloned kappa-opioid receptor to spinally projecting neurons immunoreactive for serotonin or GABA. This was done by employing two-color… CONTINUE READING

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Thus , it appears possible that the anti - analgesic action resulting from microinjection of kappa - opioid agonists into the rostral ventral medulla is mediated , at least in part , by these neurons .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Activation of kappa - opioid receptors in the rostral ventral medulla has been reported to attenuate analgesia induced by activation of mu - opioid receptors in the periaqueductal gray matter .
Thus , it appears possible that the anti - analgesic action resulting from microinjection of kappa - opioid agonists into the rostral ventral medulla is mediated , at least in part , by these neurons .
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