Serotonergic agonists and antagonists affect endurance performance in the rat.

@article{Bailey1993SerotonergicAA,
  title={Serotonergic agonists and antagonists affect endurance performance in the rat.},
  author={Stephen P. Bailey and John M Davis and E N Ahlborn},
  journal={International journal of sports medicine},
  year={1993},
  volume={14 6},
  pages={330-3}
}
The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p < 0.05) in a dose related manner by increasing dosages of quipazine dimaleate (QD: general 5-HT agonist) (0-5 mg.kg-1 i.p.) administered immediately prior to exercise (treadmill running at 20 m.min-1 and 5% grade). Conversely, RUN-EXH was increased (p < 0.05) by the greatest dosage of… CONTINUE READING

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