Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock.

@article{Edgar1997SerotonergicAM,
  title={Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock.},
  author={Dale M. Edgar and Michael S. Reid and William C. Dement},
  journal={The American journal of physiology},
  year={1997},
  volume={273 1 Pt 2},
  pages={R265-9}
}
The circadian pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus receives serotonergic afferents from the midbrain raphe nuclei, but the functional role of this projection is unclear. In rodents, locomotor activity increases serotonin content in the SCN, and serotonergic agonists phase shift the circadian clock in a manner closely similar to voluntary bouts of vigorous exercise, suggesting that serotonergic afferents could be part of the activity-dependent entrainment… CONTINUE READING
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