Serotonergic Agents in the Management of Cluster Headache

  title={Serotonergic Agents in the Management of Cluster Headache},
  author={Giorgio Lambru and Manjit Singh Matharu},
  journal={Current Pain and Headache Reports},
  • G. Lambru, M. Matharu
  • Published 28 January 2011
  • Medicine, Psychology
  • Current Pain and Headache Reports
Cluster headache is a highly disabling primary headache disorder, characterized by unilateral headache attacks occurring in association with cranial autonomic symptoms. Serotonergic agents, such as the ergot alkaloids, have traditionally been used for the acute and preventive treatment of cluster headache and other primary headaches. Although it initially was thought that their efficacy was due solely to the vasoconstriction of extracranial cerebral vessels, new mechanisms of action of these… 
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