Serosal mast cells maintain their viability and promote the metabolism of cartilage proteoglycans when cocultured with chondrocytes.

@article{Stevens1992SerosalMC,
  title={Serosal mast cells maintain their viability and promote the metabolism of cartilage proteoglycans when cocultured with chondrocytes.},
  author={Richard L. Stevens and L L Somerville and Duane A. Sewell and James R. Swafford and John P. Caulfield and Francesca Levi-Schaffer and John R. Hubbard and Elahe Talieh Dayton},
  journal={Arthritis and rheumatism},
  year={1992},
  volume={35 3},
  pages={325-35}
}
OBJECTIVE To determine the consequences of mast cell (MC)-chondrocyte interactions. METHODS Cocultured cells were analyzed histochemically, morphologically, biochemically, and functionally. RESULTS Cocultured MC adhered to the chondrocytes and remained viable. Chondrocytes cocultured with nonactivated MC produced more proteoglycans than did chondrocytes cultured alone, and these proteoglycans possessed an intact hyaluronic acid-binding region. In contrast, most of the proteoglycans produced… CONTINUE READING