Seroprevalence of n-methyl-d-aspartate glutamate receptor (NMDA-R) autoantibodies in aging subjects without neuropsychiatric disorders and in dementia patients

@article{Busse2014SeroprevalenceON,
  title={Seroprevalence of n-methyl-d-aspartate glutamate receptor (NMDA-R) autoantibodies in aging subjects without neuropsychiatric disorders and in dementia patients},
  author={Stefan Busse and Mandy Busse and Britta Brix and Christian Probst and Axel Genz and Bernhard Bogerts and Winfried Stoecker and Johann Steiner},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2014},
  volume={264},
  pages={545-550}
}
n-methyl-d-aspartate glutamate receptors (NMDA-R) play a key role in learning and memory. Therefore, they may be involved in the pathophysiology of dementia. NMDA-R autoantibodies directed against the NR1a subunit of the NMDA-R, which were first identified as a specific marker for a severe form of encephalitis, cause a decrease in NMDA-Rs, resulting in cognitive impairment and psychosis. We examined the prevalence of NR1a NMDA-R autoantibodies in the serum and cerebrospinal fluid (CSF) of 24… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry • 2017
View 2 Excerpts

Increased quinolinic acid in peripheral mononuclear cells in Alzheimer’s dementia

European Archives of Psychiatry and Clinical Neuroscience • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Nmethyl-D-aspartate receptor antibodies in herpes simplex encephalitis

H Pruss, C Finke, +12 authors KP Wandinger
Ann Neurol • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…