Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China

  title={Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China},
  author={Xin Xu and Jian Sun and Sheng Nie and Huiyuan Li and Yaozhong Kong and Min Liang and Jinlin Hou and Xianzhong Huang and Dongfeng Li and Te’an Ma and Jiaqing Peng and Shikui Gao and Yong Shao and Hong-bo Zhu and Johnson Yiu-Nam Lau and Guangyu Wang and Chunbao Xie and Li Jiang and Ailong Huang and Zhenglin Yang and Kang Zhang and Fan Fan Hou},
  journal={Nature Medicine},
Detection of asymptomatic or subclinical novel human coronavirus SARS-CoV-2 infection is critical for understanding the overall prevalence and infection potential of COVID-19. To estimate the cumulative prevalence of SARS-CoV-2 infection in China, we evaluated the host serologic response, measured by the levels of immunoglobulins M and G in 17,368 individuals, in the city of Wuhan, the epicenter of the COVID-19 pandemic in China, and geographic regions in the country, during the period from 9… 

Prevalences of SARS-CoV-2 RNA and anti-SARS-CoV-2 among at-risk populations in Chiang Mai and Lamphun provinces, Thailand, during November 2020–January 2021

Despite high exposure risk, a very high proportion was still susceptible to SARS-CoV-2 infection and would clearly benefit from vaccination, and continuing active surveillance, rolling out of vaccination and monitoring response to vaccine will help better control the COVID-19 spread.

The high level of adherence of personal protective equipment in health care workers efficiently protects them from COVID-19 infection.

The results of the current study showed high level of adherence to the use of PPE among HCWs as well as very low prevalence of seropositivity for of COVID-19 antibodies, hence confirming the effectiveness of P PE in protecting HCWs among COV VID-19 and possibly any other similar infections.

Seroprevalence of SARS-CoV-2 antibodies in over 6000 healthcare workers in Spain.

Seroprevalence of IgG-SARS-CoV-2 antibodies in HCW is a little higher than in the general population and varies depending on regional COVID-19 incidence, and the high rates of subclinical and previously undiagnosed infection observed in this study reinforce the utility of antibody screening.

Population-based seroprevalence surveys of anti-SARS-CoV-2 antibody: An up-to-date review

Seroprevalence of Antibodies to SARS-CoV-2 in Guangdong Province, China between March to June 2020

Seroprevalence of antibodies to SARS-CoV-2 was low, indicating that there were no hidden epidemics during this period and vaccination is urgently needed to increase population immunity to Sars-Cov-2.

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in admitted patients at a tertiary referral centre in North India

The seropositivity rate among hospitalized patients was found to increase with time (from 8.45% to 38%) over a period of 9 months, and Residency in Delhi and non-smokers had higher risk for seropposivity on multivariate analysis.

SARS-CoV-2 sero-prevalence in the workforces of three large workplaces in South Wales: a sero-epidemiological study

The sero-prevalence of SARS-CoV-2 antibodies varied by workplace and work role, highlighting the importance of considering COVID-19 transmission in a range of workplaces and work roles.

Seroprevalence of SARS-CoV-2 antibodies in patients with autoimmune inflammatory rheumatic diseases.

Humoral response to SARS-CoV-2 in AIIRD patients may be affected be immunosuppressive treatment, especially bDMARDs, which remained significant in the multivariate regressions adjusting for age, sex and exposure to a known COVID-19 patient.

Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19

The etiological and serological characteristics of COVID-19 are introduced, the current stage of development of human monoclonal antibodies against SARS-CoV-2 are discussed and the antigenic epitopes in the S glycoprotein are summarized, which may deepen the understanding of the profile of immune recognition and response against Sars-Cov-2 and provide insight for the design of effective vaccines and antibody-based therapies.



Antibody responses to SARS-CoV-2 in patients with COVID-19

It is suggested that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset and may be helpful for the diagnosis of suspected patients with negative RT–PCR results and for the identification of asymptomatic infections.

SARS-CoV-2 Infection in Children

Investigators in Wuhan, China, describe the spectrum of Covid-19 illness in children under the age of 16 years in SARS-CoV-2 Infection in Children.

Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

Children infected with the COVID-19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission.

Clinical Characteristics of Coronavirus Disease 2019 in China

During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China

Overall, the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization and highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.

A Novel Coronavirus Emerging in China - Key Questions for Impact Assessment.

A Novel Coronavirus Emerging in China A novel coronavirus, designated as 2019-nCoV, emerged in Wuhan, China, at the end of 2019. Although many details of the emergence of this virus remain unknown,...

The Empirical Distribution Function with Arbitrarily Grouped, Censored, and Truncated Data

SUMMARY This paper is concerned with the non-parametric estimation of a distribution function F, when the data are incomplete due to grouping, censoring and/or truncation. Using the idea of