Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

  title={Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study},
  author={L Letenneur and Karine P{\'e}r{\`e}s and H{\'e}rv{\'e} Fleury and Isabelle Garrigue and Pascale Barberger-Gateau and Catherine Helmer and J. M. Orgogozo and S. Gauthier and J F Dartigues},
  journal={PLoS ONE},
  pages={964 - 973}
BACKGROUND Herpes Simplex Virus (HSV) infection has been proposed as a possible risk factor of Alzheimer's Disease (AD) notably because it is neurotropic, ubiquitous in the general population and able to establish lifelong latency in the host. The fact that HSV was present in elderly subjects with AD suggests that the virus could be a co-factor of the disease. We investigated the risk of developing AD in anti-HSV immunoglobulin G (IgG) positive subjects (indicator of a lifelong infection to HSV… CONTINUE READING
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