Seronegative west nile meningoencephalitis diagnosed by ophthalmologic examination with subsequent seroconversion.

Abstract

PURPOSE To describe a case of seronegative West Nile virus (WNV) meningoencephalitis definitively diagnosed with ophthalmologic examination and confirmatory repeat laboratory testing. DESIGN Diagnostic case report. METHODS A patient with negative serologic testing for severe viral meningoencephalitis presented with photophobia and blurred vision 2 months after initial presentation. RESULTS Examination revealed all the classic ocular findings of WNV. Repeat serologic testing confirmed positive titers for WNV. CONCLUSIONS WNV may initially present as a severe meningoencephalitis with negative serology. Ophthalmic examination, particularly in symptomatic patients, may help with diagnosis. The ophthalmologist may play a critical role in evaluation of possible WNV meningoencephalitis.

DOI: 10.1097/ICB.0b013e31811323c9

Cite this paper

@article{Ehlers2008SeronegativeWN, title={Seronegative west nile meningoencephalitis diagnosed by ophthalmologic examination with subsequent seroconversion.}, author={Justis P. Ehlers and Joseph I Markoff and Joseph Maguire}, journal={Retinal cases & brief reports}, year={2008}, volume={2 4}, pages={312-5} }