Seronegative myasthenia gravis: clinical features, response to therapy and synthesis of acetylcholine receptor antibodies in vitro.

@article{Birmanns1991SeronegativeMG,
  title={Seronegative myasthenia gravis: clinical features, response to therapy and synthesis of acetylcholine receptor antibodies in vitro.},
  author={B Birmanns and Talma Brenner and Oded Abramsky and Israel Steiner},
  journal={Journal of the neurological sciences},
  year={1991},
  volume={102 2},
  pages={184-9}
}
Circulating autoantibodies against the acetylcholine receptor (AChR-Ab) are an important diagnostic tool in myasthenia gravis (MG). Lack of antibodies may cast doubt upon the diagnosis, the immune-mediated mechanism and the nature of the antigen. We examined clinical and laboratory features, response to immunotherapy and production of AChR-Ab in vitro, in 12 seronegative MG patients who were followed up for 2-30 years. It was possible to divide those patients into 2 groups: 7 patients with… CONTINUE READING