Seronegative Sjögren syndrome with asymptomatic autoimmune sclerosing pancreatitis

  title={Seronegative Sj{\"o}gren syndrome with asymptomatic autoimmune sclerosing pancreatitis},
  author={M Matsuda and Hideaki Hamano and Takuhiro Yoshida and Takahisa Gono and Takeshi Uehara and Shigeyuki Kawa and Shu-ichi Ikeda},
  journal={Clinical Rheumatology},
We report two elderly patients with seronegative Sjögren syndrome who showed benign swelling of the pancreas on computed tomography. Immunostaining of the biopsied lip tissue or serum examination confirmed an increase in production of IgG4, leading to a diagnosis of autoimmune sclerosing pancreatitis (ASP) as a cause of the asymptomatic swelling of the pancreas. Sicca symptoms and ASP spontaneously improved in one patient, and the other responded well to oral prednisolone. Seronegative Sjögren… CONTINUE READING


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