Seronegative Hashimoto thyroiditis with thyroid autoantibody production localized to the thyroid.

@article{Baker1988SeronegativeHT,
  title={Seronegative Hashimoto thyroiditis with thyroid autoantibody production localized to the thyroid.},
  author={James R Baker and Nancy B. Saunders and Leonard Wartofsky and Ying Chi Tseng and Kenneth D. Burman},
  journal={Annals of internal medicine},
  year={1988},
  volume={108 1},
  pages={26-30}
}
A patient without serologic evidence of an autoimmune disorder had a thyroidectomy for neck compression caused by her goiter. Histologic examination of the gland revealed pathologic changes compatible with Hashimoto disease, and lymphocytes isolated from her thyroid gland were transformed into lymphoblastoid cells in vitro by Epstein-Barr virus in the presence of cyclosporine. These cells produced antibodies against thyroglobulin, thyroid microsome, thyrocyte membrane, and thyrotropin, whereas… CONTINUE READING

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