Serological immunoreactivity against colon cancer proteome varies upon disease progression.

  title={Serological immunoreactivity against colon cancer proteome varies upon disease progression.},
  author={Lucia De Monte and Francesca Sanvito and Stefano Olivieri and Fiammetta Vigan{\`o} and Claudio Doglioni and Matteo Frasson and M. Braga and Angela Bachi and Paolo Dellabona and Maria Pia Protti and Massimo Alessio},
  journal={Journal of proteome research},
  volume={7 2},
Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa. 

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