Serological differentiation of acute and chronic schistosomiasis using Schistosoma mansoni recombinant protein RP26.

@article{Makarova2003SerologicalDO,
  title={Serological differentiation of acute and chronic schistosomiasis using Schistosoma mansoni recombinant protein RP26.},
  author={Elena N. Makarova and T{\'e}rcio S Goes and A L M Marcatto and Maria de F{\'a}tima M. P. Leite and Alfredo de Miranda G{\'o}es},
  journal={Parasitology international},
  year={2003},
  volume={52 4},
  pages={269-79}
}
We obtained a recombinant protein encoded by Schistosoma mansoni gene which was able to differentiate acute from chronic schistosomiasis when applied as antigen in enzyme-linked immunosorbent assay (ELISA). A cDNA clone encoding a 26 kDa recombinant protein (RP26) was selected by screening of an adult worm S. mansoni lambdaZAP expression library with rabbit sera produced against PIII, an adult worm protein fraction already known to possess protective and immunomodulating effects. The clone cDNA… CONTINUE READING

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