Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma.

@article{Unwin2003SerologicalAP,
  title={Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma.},
  author={Richard D. Unwin and Patricia M Harnden and Darryl J. Pappin and Dinah Rahman and Peter Whelan and Rachel A. Craven and Peter John Selby and Rosamonde E. Banks},
  journal={Proteomics},
  year={2003},
  volume={3 1},
  pages={45-55}
}
Renal cell carcinoma (RCC) is relatively resistant to conventional chemotherapy and radiotherapy. However, reports of spontaneous regression along with promising results in clinical trials suggest that immunotherapuetic strategies may be of clinical benefit. Few RCC related antigens have been identified to date, and the technical difficulty and time constraints of current antigen identification techniques preclude the screening of large numbers of patients. A comparatively rapid strategy has… CONTINUE READING