Serological and biochemical characterization of rat (RT1) class II molecules with restricted mouse anti-Ia sera

@article{Wettstein1981SerologicalAB,
  title={Serological and biochemical characterization of rat (RT1) class II molecules with restricted mouse anti-Ia sera},
  author={Peter J. Wettstein and John G. Frelinger and L. Hood},
  journal={Immunogenetics},
  year={1981},
  volume={13},
  pages={93-107}
}
Murine anti-Ia sera were tested for their reactivity with rat peripheral lymphocytes. Extensive cross-reactions were observed in a complement-dependent cytotoxicity assay. In the majority of strain combinations, these reactions were specific for B cells. We demonstrated by absorption analyses that (1) the reaction was specific, (2) B cells from all rat strains reacted with anti-I-Ek serum, and (3) the anti-I-A sera defined five new specificities. These antisera can also immunoprecipitate class… CONTINUE READING
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