Serological Tests in Gluten Sensitivity (Nonceliac Gluten Intolerance)

  title={Serological Tests in Gluten Sensitivity (Nonceliac Gluten Intolerance)},
  author={Umberto Volta and Francesco Tovoli and Ronny Cicola and Claudia Parisi and Angela Fabbri and Maria Piscaglia and Erica Fiorini and Giacomo Caio},
  journal={Journal of Clinical Gastroenterology},
Goals: To characterize the serological pattern of gluten sensitivity (GS) and to compare it with that found in celiac disease. Background: GS has recently been identified as a new clinical entity included in the spectrum of gluten-related disorders, but it is still lacking of diagnostic markers. Study: Sera from 78 patients with GS and 80 patients with celiac disease were retrospectively assessed for immunoglobulin (Ig)G/IgA antigliadin antibodies (AGA), IgG deamidated gliadin peptide… 

Diagnostic accuracy of anti-gliadin antibodies in Non Celiac Gluten Sensitivity (NCGS) patients: A dual statistical approach.

Diagnosis and classification of celiac disease and gluten sensitivity.

Prevalence of Anti-deamidated Gliadin Peptide Antibodies in Asian Patients With Irritable Bowel Syndrome

This is the first report of non-celiac gluten sensitivity in Asia, a region where CD is uncommon, and patients with IBS who were tested positive for IgA DGP, and improved on a gluten exclusion diet are described.

Intestinal, Systemic, and Oral Gluten-related Alterations in Patients With Nonceliac Gluten Sensitivity

GOMPT seems to be a specific tool for NCGS diagnosis, although further investigations are needed to overcome limits due to the small population studied and to contextualize GOMPT false-positive results.

Celiac Disease and Nonceliac Gluten Sensitivity: A Review

Although both conditions are treated with a gluten-free diet, distinguishing between celiac disease and nonceliac gluten sensitivity is important for long-term therapy.

Anti-gliadin Antibodies and Gluten Neuropathies: A Borderline Link.

Gluten Sensitivity is a potential cause of unknown etiological neurologic diseases in young adults, particularly peripheral neuropathy, ataxia and ischemic stroke, and AGA testing especially IgG isotype might be a suitable marker to screen for gluten neuropathies.

Non-celiac gluten sensitivity: a work-in-progress entity in the spectrum of wheat-related disorders.

Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity

In non-celiac gluten sensitivity patients anti-gliadin antibodies IgG persistence after gluten withdrawal was significantly correlated with the low compliance to gluten-free diet and a mild clinical response.

Serological screening for celiac disease in adults in Japan: Shimane CoHRE study

Among a general population in Japan, a positive rate of serological tests for CD was noted in 0.19%, indicating quite a low presence, consistent with previous results.



Deamidated Gliadin Peptide Antibodies as a Routine Test for Celiac Disease: A Prospective Analysis

The prospective study shows that the combined search for IgA tTGA and IgG DGP-AGA provides the best diagnostic accuracy for CD, allowing the identification of all CD cases---except one---with a very high specificity.

Cutting-Edge Issues in Celiac Disease and in Gluten Intolerance

Some relevant aspects related to the laboratory diagnosis of CD and, more extensively, of gluten intolerance are considered, such as the best combination of tests for early and accurate diagnosis, the diagnostic role of new tests for detecting antibodies against neoepitopes produced by the transglutaminase–gliadin complex, the forms of non-celiac gluten intolerance (gluten sensitivity), and the use and significance of measuring cytokines in CD.

IgA antigliadin antibodies and persistence of jejunal lesions in adult coeliac disease.

Though intestinal biopsy remains the best means of determining the positive effect of gluten withdrawal, the persistence of IgA AGA in treated coeliacs is always predictive of the persistenceOf severe jejunal lesions.

Human umbilical cord as substrate for IgA antiendomysial antibodies allows large scale screening for celiac sprue.

It is proved that the routine use of IgA HUC-EmA increases celiac sprue findings by up to 15% when compared with AGA.

High Prevalence of Celiac Disease in Italian General Population

It is demonstrated that celiac disease prevalence in the Italian general population is 4.9 per 1000 (95% CI 2.8–7.8), increasing up to 5.7 per 1000 with the inclusion of potential cases, and was more frequent in younger age groups.

Intolerance to cereals is not specific for coeliac disease.

Intolerance to cereals is not a specific sign of overt or latent coeliac disease, and all experimental dietary interventions before proper diagnosis of coeliak disease are to be discouraged.

Celiac disease in autoimmune cholestatic liver disorders

The high prevalence of CD in autoimmune cholestasis suggests that serological screening for CD should be routinely performed in such patients by immunoglobulin A endomysial or human tissue transglutaminase antibodies.

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

This study shows that the two gluten-associated disorders, CD and GS, are different clinical entities, and it contributes to the characterization of GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.

Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.

HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.