Serological Markers and HLA-DQ2 Haplotype Among First-Degree Relatives of Celiac Patients

  title={Serological Markers and HLA-DQ2 Haplotype Among First-Degree Relatives of Celiac Patients},
  author={Carme Farr{\'e} and Pere Humbert and Pere Vilar and Vicente R. Varea and Xavier Aldeguer and Jesus Carnicer and Miguel Carballo and Miquel Angel Gassull},
  journal={Digestive Diseases and Sciences},
Serologic markers, HLA-DQ2 haplotype, andclinical features suggestive of celiac disease werestudied to assess their diagnostic value in amulticentric study to detect celiac disease in 675first-degree relatives of 227 celiac probands. SerumIgA-class anti-endomysium and IgA-class anti-gliadinantibodies were positive in 5.8% and 1.9% of relatives,respectively. HLA-DQ2 haplotype was present in 64% of relatives, and the overall rate of celiacdisease diagnosed by intestinal biopsy was 5.5… CONTINUE READING
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