Serologic responses of children with meningitis due to Haemophilus influenzae type b.

@article{Norden1976SerologicRO,
  title={Serologic responses of children with meningitis due to Haemophilus influenzae type b.},
  author={Carl W. Norden and Richard H. Michaels and Marian E. Melish},
  journal={The Journal of infectious diseases},
  year={1976},
  volume={134 5},
  pages={
          495-9
        }
}
The immunologic responses of 100 children hospitalized with meningitis due to Haemophilus influenzae type b were measured by the bactericidal antibody assay (BAA) and radioimmunoassay (RIA) for detection of antibody. Short-term (14-17 days after onset of illness) responses were detected by RIA alone in 20 children, by BAA alone in six, and by both tests in 23. The more sensitive RIA detected 20 children who would have been labeled "immunologically unresponsive" had only BAA been used. The… 
Characterization of the serum antibody response to the capsular polysaccharide of Haemophilus influenzae type b in children with invasive infections.
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The serum antibody response to the capsular polysaccharide of Haemophilus influenzae type b (Hib) was studied in 30 children aged 1 day-5 years with invasive Hib infections with wide individual variations.
Immunization after invasive Haemophilus influenzae type b disease. Serologic response to a conjugate vaccine.
TLDR
Although children with previous invasive H influenzae type b disease do not respond as vigorously to conjugate vaccine as do previously healthy controls, the response is sufficient to justify routine immunization of such children.
Human antibody responses to lipopolysaccharide after meningitis due to Haemophilus influenzae type b.
TLDR
The presence of high levels of antibodies to LPS in the sera of half of the acutely ill children suggests that antibodies to some LPS determinants are not protective, whereas children with lower initial levels showed high responses.
Management of recurrent invasive Haemophilus influenzae infection.
A 4 1/2-month-old infant had three separate episodes of invasive Haemophilus influenzae type b infection and did not produce antibody to the capsular polysaccharide of H influenzae b. Immunologic
Haemophilus influenzae type b infections.
TLDR
An epidemiological investigation of immediate contacts including history, physical examination, nasopharyngeal cultures, and paired serum determinations for capsular antibody titers by radioimmunoassay technique found positive findings.
Anti-polyribosylribitol phosphate antibody in pediatric patients with Haemophilus influenzae type b invasive disease
TLDR
Serum anti-polyribosylribitol phosphate antibody responses of patients <2 years old were poorer than those observed in patients ≥2  years old, and children <4 yearsOld, and particularly <2-years old, with invasive H. influenzae type b disease should receive subsequent immunization with a H. Influenzaetype b conjugate vaccine.
Use of rifampin in Haemophilus influenzae type b infections.
  • K. Li, E. Wald
  • Medicine, Biology
    American journal of diseases of children
  • 1986
TLDR
The data suggest that rifampin given concurrently with therapeutic antimicrobials is as effective-89% (17/19)--as when given following therapeutic antim Microbials-95%--in eradicating pharyngeal HIB.
Serum antibody response to capsular polysaccharide, outer membrane, and lipooligosaccharide in children with invasive Haemophilus influenzae type b infections
Serum antibodies against capsular polysaccharide (CPS), outer membrane (OM), and lipooligosaccharide (LOS) from Haemophilus influenzae type b were measured by enzyme-linked immunosorbent assay in
Occurrence of HLA types in H. influenzae type B disease.
TLDR
Findings would suggest that susceptibility and resistance towards developing invasive type b disease may be genetically determined in Caucasoid children under 7 years of age.
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