Serologic markers in inflammatory bowel disease: tools for better diagnosis and disease stratification

@article{Dotan2007SerologicMI,
  title={Serologic markers in inflammatory bowel disease: tools for better diagnosis and disease stratification},
  author={Iris Dotan},
  journal={Expert Review of Gastroenterology \& Hepatology},
  year={2007},
  volume={1},
  pages={265 - 274}
}
  • I. Dotan
  • Published 1 December 2007
  • Medicine
  • Expert Review of Gastroenterology & Hepatology
In the last decade, new serologic markers have been identified, and attempts to delineate their potential roles in inflammatory bowel disease diagnosis, determination of prognosis and identification of apparently healthy subjects at risk have significantly increased our knowledge. In this review, the major serologic markers will be described, focusing on their common features as a group. It is predicted that within the next 5 years, panels of antibodies will prove to have a significant impact… 
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11 Citations
Highly Influential Citations
1
Background Citations
4
Methods Citations
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11 Citations

Antibody markers in the diagnosis of inflammatory bowel disease.
TLDR
No single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest, and the discovery of novel IBD-specific and sensitive markers is anticipated.
Clinical Utility of Biomarkers in IBD
TLDR
This overview is structured in chapters reflecting those four typical situations during the disease course of IBD patents to critically evaluate the potential and value of each of the biomarkers in the specific situation.
Serological Markers in Inflammatory Bowel Disease
TLDR
Serological markers linked to CD, such as anti-Saccaromyces cerevisiae, anti-Pseudomonas-associated sequence I2, outer membrane porin C of Escherichia coli antibodies and antibodies against the bacterial flagellin CBir1, as well as markers linked as perinuclear anti-neutrophil cytoplasmic antibodies, p-ANCA, have been extensively investigated for diagnosis and disease stratification.
[New approaches to diagnosing and treating Crohn's disease].
TLDR
Current views on the diagnosis and medical treatment of Crohn's disease are presented and promising treatment options, which affect the key molecules of the pathogenesis of this disease, are considered.
Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease
TLDR
There exists a long delay in a considerable proportion of CD patients, and more public awareness work needs to be done in order to reduce patient and doctor delays in this target population.
Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease
TLDR
The findings suggest serum miRNAs may prove useful as noninvasive biomarkers in CD, with promising diagnostic utility, with sensitivities for CD above 80%.
Inflammatory bowel disease
TLDR
This presentation of IBD gives a brief overview in the fields of clinical epidemiology and molecular biology, and can clearly support the view that global perspectives in IBD are increasingly important.
Microbial etiology of Inflammatory Bowel Disease: Microbial diversity and the role of Escherichia coli
TLDR
A remarkable increase in the order of unclassified Clostridia was detected in inflamed tissues, particularly in CD patients, and species richness and diversity were the highest in non-inflamed IBD biopsies.
COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT AND DAGNOSIS OF NFLAMMLATORY BOWEL DISEASE
TLDR
A comparison of microRNA signatures of tumor-dervied exosomes as diagnostic biomarkers of ovarian cancer and that of pediatric Crohn disease shows that microRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2a.
RETRACTED ARTICLE: Mouse models of intestinal inflammation and cancer
TLDR
Potential mechanisms of pathogenesis in inflammatory bowel diseases and celiac disease, as well as those involved in the progression to associated cancers, are highlighted, most of which have been identified from studies utilizing mouse models of intestinal inflammation.
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