Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays.

  title={Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays.},
  author={Patrick Joseph Waters and Andrew Mckeon and M. Isabel Leite and Sathy Rajasekharan and Vanda A. Lennon and Aurora Villalobos and Jackie Palace and Jayawant Mandrekar and Angela Vincent and Amit Bar-Or and Sean J. Pittock},
  volume={78 9},
  pages={665-71; discussion 669}
OBJECTIVES Neuromyelitis optica (NMO) immunoglobulin G (IgG) (aquaporin-4 [AQP4] IgG) is highly specific for NMO and related disorders, and autoantibody detection has become an essential investigation in patients with demyelinating disease. However, although different techniques are now used, no multicenter comparisons have been performed. This study compares the sensitivity and specificity of different assays, including an in-house flow cytometric assay and 2 commercial assays (ELISA and… CONTINUE READING
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