Serologic and molecular characterization of the T15 idiotype--II. Structural basis of independent idiotope expression on phosphorylcholine-specific monoclonal antibodies.

@article{Strickland1987SerologicAM,
  title={Serologic and molecular characterization of the T15 idiotype--II. Structural basis of independent idiotope expression on phosphorylcholine-specific monoclonal antibodies.},
  author={Faith M. Strickland and J T Gleason and Jan {\vC}ern{\'y}},
  journal={Molecular immunology},
  year={1987},
  volume={24 6},
  pages={637-46}
}
We examined the expression of T15 idiotopes (Id) on phosphorylcholine (PC)-binding monoclonal immunoglobulins and defined the structural correlates of these Id. The seven monoclonal anti-Id antibodies used as probes recognize distinct determinants that range from the antigen binding site to the CH1 domain on TEPC15. Competition between a series of PC-specific immunoglobulins and radiolabelled TEPC15 for binding to anti-Id in solid phase revealed a broad spectrum of idiotopic crossreactivity. A… CONTINUE READING

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