Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates.

@article{Bacon2003SerodiagnosisOL,
  title={Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates.},
  author={Rendi Murphree Bacon and Brad J. Biggerstaff and Martin E. Schriefer and Robert D Gilmore and Mario T. Philipp and Allen C. Steere and Gary P. Wormser and Adriana R Marques and Barbara J. B. Johnson},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={187 8},
  pages={1187-99}
}
In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorferi antigen VlsE1 (rVlsE1), IgG responses to a synthetic peptide homologous to a conserved internal sequence of VlsE (C6), and IgM responses to a synthetic peptide comprising the C-terminal 10 amino acid residues of a B. burgdorferi outer-surface protein C (pepC10) were evaluated by kinetic enzyme-linked immunoassay. At 99% specificity, the overall sensitivities for… CONTINUE READING

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