Serious Doubts on Safety and Efficacy of CCR5 Antagonists

@article{Horster2006SeriousDO,
  title={Serious Doubts on Safety and Efficacy of CCR5 Antagonists},
  author={Sophia Horster and Frank D. Goebel},
  journal={Infection},
  year={2006},
  volume={34},
  pages={110-113}
}
Entry inhibitors constitute a new drug class for treatment of HIV-1 infection. They are divided into subclasses, each aiming at a crucial step during the complex event of HIV entry into the target cell. Attachment inhibitors are designed to prevent the HIV envelope glycoprotein gp120 attachment to CD4 receptors, co-receptor antagonists to inhibit, e.g. CCR5 co-receptor binding after conformational changes within gp120 and fusion inhibitors to hamper fusion of viral and cellular membranes, the… 
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