Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.

OBJECTIVE This study aimed to investigate the effects of serine threonine kinase Pim-3 on the growth of HepG2 cells and to explore the role of STAT3 signaling pathway. METHODS Synthetic Pim-3shRNA and negative control shRNA were independently transfected into HepG2 cells in the presence of Lipofectamine(TM) 2000. Cells were divided into 4 groups: Pim-3… CONTINUE READING