Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.

@article{Bossenmaier2000SerineR1,
  title={Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.},
  author={Birgit Bossenmaier and Volker Strack and Borislav Stoyanov and Jan Kr{\"u}tzfeldt and Alexander Maximilian Beck and Rainer Lehmann and Monika Kellerer and Hermann H. Klein and Axel Prof Dr Ullrich and Reiner Lammers and H. U. H{\"a}ring},
  journal={Diabetes},
  year={2000},
  volume={49 6},
  pages={
          889-95
        }
}
Serine residues of the human insulin receptor (HIR) may be phosphorylated and negatively regulate the insulin signal. We studied the impact of 16 serine residues in HIR by mutation to alanine and co-overexpression in human embryonic kidney (HEK) 293 cells together with the docking proteins insulin receptor substrate (IRS)-1, IRS-2, or (SHC) Src homologous and collagen-like. As a control, IRS-1 was also cotransfected with an HIR with a juxtamembrane deletion (HIR delta JM) and therefore not… CONTINUE READING

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