Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9‐dependent manner

@article{Takarada2008SerineRS,
  title={Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9‐dependent manner},
  author={T. Takarada and E. Hinoi and Yoshifumi Takahata and Y. Yoneda},
  journal={Journal of Cellular Physiology},
  year={2008},
  volume={215}
}
Serine racemase (SR) is responsible for the biosynthesis of D‐serine (D‐Ser), an endogenous co‐agonist for N‐methyl‐D‐aspartate (NMDA) receptors, from L‐serine (L‐Ser) in the central nervous system. In the present study, we investigated the role of SR in the regulation of chondrogenic differentiation in cartilage. On in situ hybridization analysis of tibia from neonatal rats, SR mRNA was ubiquitously expressed in all cell layers of proliferating to hypertrophic chondrocytes. In the pre… Expand
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