Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration.

@article{Kim2005SerineRA,
  title={Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration.},
  author={Paul Kim and Hiroyuki Aizawa and Peter S. Kim and Alex S Huang and Sasrutha R Wickramasinghe and Amir H Kashani and Roxanne K. Barrow and Richard L. Huganir and Anirvan Ghosh and Solomon H Snyder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 6},
  pages={2105-10}
}
Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR. GRIP physiologically binds SR, augmenting SR activity and D-serine release. GRIP… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

References

Publications referenced by this paper.

Psychopharmacology: The Fourth Generation of Progress

  • D. A. Gorelick, R. L. Balster
  • 1995

Similar Papers

Loading similar papers…