Serine proteases increase oxidative stress in lung cells.

  title={Serine proteases increase oxidative stress in lung cells.},
  author={Kazutetsu Aoshiba and Koubun Yasuda and Shuji Yasui and Jun Tamaoki and Atsushi Nagai},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={281 3},
Several serine proteases are directly cytotoxic. We investigated whether the cytotoxic effects of proteases are associated with increased levels of reactive oxygen species (ROS) in cells. We found that treatment of lung fibroblasts or bronchial epithelial cells with relatively high concentrations (0.1--100 U/ml) of neutrophil elastase, trypsin, and Pronase increased ROS levels in the mitochondria and cytoplasm. The protease-induced increase in ROS was associated with oxidative cellular injury… CONTINUE READING
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