Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.

@article{Bowden2006SerinePH,
  title={Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.},
  author={M. D. Talmadge A. Bowden and Lisa A Di Nezza-Cossens and Tom W. Jobling and Lois A. Salamonsen and Guiying Nie},
  journal={Gynecologic oncology},
  year={2006},
  volume={103 1},
  pages={253-60}
}
OBJECTIVE The high temperature requirement factor A (HTRA) family consists of serine proteases with domains homologous to those of bacterial HTRA. Four human HTRA members have been described: HTRA1-4. HTRA1 and HTRA3 share a high degree of domain homologies and may therefore share a functional similarity. HTRA1 mRNA and protein is reported to be down-regulated in SV40-transformed cells, a malignant melanoma cell line, ovarian tumors, and ovarian cancer cell lines, suggesting a progressive loss… CONTINUE READING

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