Serine protease signaling of epidermal permeability barrier homeostasis.

@article{Hachem2006SerinePS,
  title={Serine protease signaling of epidermal permeability barrier homeostasis.},
  author={J P Hachem and Evi Houben and Debra C Crumrine and Mao-Quiang Man and Nanna Y Schurer and Truus Roelandt and Eung Ho Choi and Yoshikazu Uchida and Barbara E. Brown and Kenneth R. Feingold and Peter M Elias},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 9},
  pages={2074-86}
}
Evidence is growing that protease-activated receptor-2 (PAR-2) plays a key role in epithelial inflammation. We hypothesized here that PAR-2 plays a central role in epidermal permeability barrier homeostasis by mediating signaling from serine proteases (SP) in the stratum corneum (SC). Since the SC contains tryptic- and chymotryptic-like activity, we assessed the influence of SP activation/inhibition on barrier function. Acute barrier disruption increases SP activity and blockade by topical SP… CONTINUE READING

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