Serine protease signaling of epidermal permeability barrier homeostasis.

  title={Serine protease signaling of epidermal permeability barrier homeostasis.},
  author={J P Hachem and Evi Houben and Debra C Crumrine and Mao-Quiang Man and Nanna Y Schurer and Truus Roelandt and Eung Ho Choi and Yoshikazu Uchida and Barbara E. Brown and Kenneth R. Feingold and Peter M Elias},
  journal={The Journal of investigative dermatology},
  volume={126 9},
Evidence is growing that protease-activated receptor-2 (PAR-2) plays a key role in epithelial inflammation. We hypothesized here that PAR-2 plays a central role in epidermal permeability barrier homeostasis by mediating signaling from serine proteases (SP) in the stratum corneum (SC). Since the SC contains tryptic- and chymotryptic-like activity, we assessed the influence of SP activation/inhibition on barrier function. Acute barrier disruption increases SP activity and blockade by topical SP… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 60 extracted citations

Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid

Biomolecules & therapeutics • 2016
View 3 Excerpts
Highly Influenced

Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction.

The Journal of investigative dermatology • 2010
View 5 Excerpts
Highly Influenced

Skin neurogenic inflammation

Seminars in Immunopathology • 2018

Daily Routine in Cosmetic Dermatology

Clinical Approaches and Procedures in Cosmetic Dermatology • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…