Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.

@article{Kalaria1993SerinePI,
  title={Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.},
  author={Raj N Kalaria and Todd E Golde and Stephanie N. Kroon and George Perry},
  journal={The American journal of pathology},
  year={1993},
  volume={143 3},
  pages={886-93}
}
The classical plasma protein antithrombin III (ATIII), an inhibitor of the blood coagulation cascade, is a member of the serpins that are gaining import in the nervous system. In this study, we examined the presence of ATIII in the pathological lesions of Alzheimer's disease (AD). Antibodies to ATIII consistently detected approximately 58-kd protein(s) on immunoblots of cerebral cortex and brain microvessels. Immunocytochemical studies showed ATIII reactivity within amyloid deposits, neurites… CONTINUE READING

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