Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice.

@article{Bot2003SerinePI,
  title={Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice.},
  author={Ilze Bot and Jan H. von der Th{\"u}sen and M Donners and Alexandra Lucas and Madelon L. Fekkes and Saskia C.A. de Jager and J. J. W. Kuiper and Mat J. A. P. Daemen and Theo J. C. van Berkel and Sylvia Heeneman and Erik Anna Leonardus Biessen},
  journal={Circulation research},
  year={2003},
  volume={93 5},
  pages={464-71}
}
The myxoma virus protein Serp-1 is a member of the serine protease inhibitor superfamily. Serp-1 potently inhibits human serum proteases including plasmin, urokinase-type plasminogen activator (uPA), and tissue-type plasminogen activator (tPA). Serp-1 also displays a high antiinflammatory activity, rendering it a promising candidate for antiatherosclerotic… CONTINUE READING