Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.

@article{Tegtmeyer2011SerinePO,
  title={Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.},
  author={Nicole Tegtmeyer and Ruth Wittelsberger and Roland Hartig and Silja Wessler and Narcisa Mart{\'i}nez-Quiles and Steffen Backert},
  journal={Cell host & microbe},
  year={2011},
  volume={9 6},
  pages={520-31}
}
Cell migration and invasion require the coordinated regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination. We show that the gastric pathogen Helicobacter pylori (Hp) targets cortactin by two independent processes leading to its tyrosine dephosphorylation and serine phosphorylation to regulate cell scattering and… CONTINUE READING