Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

@article{Garcia1991SerinePD,
  title={Serine phosphorylation-independent downregulation of cell-surface CD4 by nef},
  author={J. Garcia and A. Miller},
  journal={Nature},
  year={1991},
  volume={350},
  pages={508-511}
}
A DECLINE in the T-cell population usually marks the onset of progressive immunological disease in individuals infected with the human immunodeficiency virus (HIV). Because CD4+ cells help to coordinate efficient immune responses, some of the defects in the immune function in advanced cases of AIDS may be explained by the disappearance of these cells. Therefore, an understanding of the mechanisms used by HIV to induce the reduction of CD4+ cells is important. Here we use a Moloney murine… Expand
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