Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis.

@article{Perry2000SerinePR,
  title={Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis.},
  author={David K. Perry and Jill Carton and Asist K Shah and Filmore I. Meredith and D J Uhlinger and Yusuf A. Hannun},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 12},
  pages={9078-84}
}
The de novo pathway of sphingolipid synthesis has been identified recently as a novel means of generating ceramide during apoptosis. Furthermore, it has been suggested that the activation of dihydroceramide synthase is responsible for increased ceramide production through this pathway. In this study, accumulation of ceramide mass in Molt-4 human leukemia cells by the chemotherapy agent etoposide was found to occur primarily due to activation of the de novo pathway. However, when the cells were… CONTINUE READING

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